Research is vital in increasing our understanding of HD, improving the quality of life for those impacted by HD, and also providing hope for viable treatments and a cure.
Research continues to progress through the collaboration between you-our community, our invaluable HD researchers and your association. When you participate in research, your contribution not only helps in the study you are involved in, but is often a starting point for new or further research.
Huntington’s Victoria proudly partners with the Huntington’s Research Group of Victoria (HRGV) who are extremely active in HD research. You can view some of the local research below, and find out how you can become involved.
Exploring computational modelling to predict disease progression in Huntington’s Disease using combined IMAGE-HD, PREDICT-HD and TRACK-HD datasets
RESEARCH DATE: 07/10/2019
Applications of computational modeling in Huntington’s disease is a promising avenue in research directing towards predicting the disease progression. In the past few years, researchers have shown the positive impacts of modeling the disease progression to find the most sensitive biomarkers not only in Huntington’s disease but also in other neurodegenerative disease such as Alzheimer’s’ disease. We are interested in applying computational modeling techniques to the combined data sets from IMAG-HD, PREDICT-HD and TRACK-HD studies to find a model that could explain the disease progression across studies with high accuracy. In the process of developing the model we aim explore and incorporate not only the clinical measures but also the behavioral and imaging measures and find the best combination of measures that results in the highest predictability of disease progression. These modelling techniques will be crucial to understand the level of contribution of each measure to disease progression which then can be used in the advancement of developing more effective treatment methods or therapeutical approaches targeting the most sensitive measures, to delay the neural degeneration and the subsequent onset of the Huntington’s disease.
We want to investigate a new app which we hope will assist both patients and health professionals to better understand how someone’s driving is going. On-road driving assessments can be quite expensive, and so we are hoping to improve a specially designed iPad app that could save people from going for an expensive driving assessment before they need to.
Over the past two decades, our research team has played a key role in understanding how the ‘genetic stutter’ causing Huntington’s disease (HD) leads to a cascade of pathological processes, at the levels of molecules, cells, brain circuits, behaviour, cognition and mood. HD is one of a growing number of human diseases known to be caused by such ‘genetic stutters’, which are called tandem repeat disorders (reviewed by Hannan, 2018, Nature Rev. Genet.)
There are currently no effective treatments for apathy (loss of motivation) caused by HD. I am conducting this study to find out whether transcranial alternating current stimulation (tACS), a gentle non-invasive brain stimulation technique, can alter brain activity in a way that may be used to increase motivation in people with Huntington’s disease (HD).
Wave Life Sciences PRECISION- HD1 and PRECISION-HD2 Clinical trials Wave Life Sciences are conducting two Phase 1b/2a clinical trials called PRECISION-HD1 and PRECISION-HD2. These trials aim to specifically target and reduce the amount of mutant huntingtin protein produced, whilst leaving the healthy huntingtin protein untouched. The treatments will be administered into the fluid in the […]